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UniProt functional annotation for P04043 | ||
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| UniProt code: P04043. |
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| Organism: | |
Streptococcus pneumoniae. |
| Taxonomy: | |
Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus. |
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| Function: | |
This methylase recognizes the double-stranded sequence GATC, causes specific methylation on A-2 on both strands, and protects the DNA from cleavage by the DpnII endonuclease. |
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| Catalytic activity: | |
Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA- COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72; |
| Subunit: | |
Homodimer. |
| Miscellaneous: | |
The DpnII restriction system has two different methylases. |
| Similarity: | |
Belongs to the N(4)/N(6)-methyltransferase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.