UniProt functional annotation for Q8CCN1



	UniProt functional annotation for Q8CCN1

UniProt code: Q8CCN1.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID (By similarity). Displays anti- inflammatory activity (By similarity). Required for immunity against C.albicans infection (PubMed:23071280). Involved in the innate immune response by contributing to proinflammatory cytokine release in response to invasive bacterial infection (By similarity). Contributes to T-cell-mediated inflammatory responses in the skin (PubMed:27221772). Plays a role in protection against periodontitis through its involvement in induction of IL1A via ERK activation in oral epithelial cells infected with periodontal pathogens (By similarity). Exhibits both ATPase and GTPase activities (By similarity). {ECO:0000250|UniProtKB:Q86W26, ECO:0000269|PubMed:23071280, ECO:0000269|PubMed:27221772}.

Subunit: Oligomerizes (By similarity). Interacts with PYCARD (By similarity). Also interacts with CASP1 and IL1B (PubMed:15096476). Interacts with NOD1 and components of the NOD1 signaling pathway including RIPK2, NR2C2/TAK1 and IKBKG/NEMO (By similarity). {ECO:0000250|UniProtKB:Q86W26, ECO:0000269|PubMed:15096476}.

Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:Q86W26}. Cell membrane {ECO:0000250|UniProtKB:Q86W26}; Peripheral membrane protein {ECO:0000305}. Note=Cytoplasmic protein which is recruited to the cell membrane by NOD1 following invasive bacterial infection. {ECO:0000250|UniProtKB:Q86W26}.

Tissue specificity: Expressed in skin, tongue, heart, colon and several cell lines of hematopoietic and myocytic origin but not in kidney, skeletal muscle, spleen, liver, lung, thymus, brain or small intestine (at protein level). {ECO:0000269|PubMed:20393137}.

Domain: The pyrin and ATP-binding domains are required to elicit cytokine release following bacterial infection. {ECO:0000250}.

Domain: The NACHT domain is required for inhibition of CASP1 autoprocessing. {ECO:0000250}.

Disruption phenotype: High susceptibility to systemic infection by C.albicans with 100% mortality by day 16 post-infection (PubMed:23071280). Does not alter Nlrp3 inflammasome activity and up- regulates Gdpd3 expression (PubMed:22538615). Does not impair skin repair after wounding (PubMed:27221772). Also does not impair the irritant contact dermatitis response following treatment with the irritant croton oil (PubMed:27221772). Significantly reduced inflammation in dinitrofluorobenzene-induced contact hypersensitivity response with reduced numbers of CD3(+), CD8(+) and CD4(+) T cells (PubMed:27221772). {ECO:0000269|PubMed:22538615, ECO:0000269|PubMed:23071280, ECO:0000269|PubMed:27221772}.

Similarity: Belongs to the NLRP family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID (By similarity). Displays anti- inflammatory activity (By similarity). Required for immunity against C.albicans infection (PubMed:23071280). Involved in the innate immune response by contributing to proinflammatory cytokine release in response to invasive bacterial infection (By similarity). Contributes to T-cell-mediated inflammatory responses in the skin (PubMed:27221772). Plays a role in protection against periodontitis through its involvement in induction of IL1A via ERK activation in oral epithelial cells infected with periodontal pathogens (By similarity). Exhibits both ATPase and GTPase activities (By similarity). {ECO:0000250\|UniProtKB:Q86W26, ECO:0000269\|PubMed:23071280, ECO:0000269\|PubMed:27221772}.


Subunit:		Oligomerizes (By similarity). Interacts with PYCARD (By similarity). Also interacts with CASP1 and IL1B (PubMed:15096476). Interacts with NOD1 and components of the NOD1 signaling pathway including RIPK2, NR2C2/TAK1 and IKBKG/NEMO (By similarity). {ECO:0000250\|UniProtKB:Q86W26, ECO:0000269\|PubMed:15096476}.
Subcellular location:		Cytoplasm {ECO:0000250\|UniProtKB:Q86W26}. Cell membrane {ECO:0000250\|UniProtKB:Q86W26}; Peripheral membrane protein {ECO:0000305}. Note=Cytoplasmic protein which is recruited to the cell membrane by NOD1 following invasive bacterial infection. {ECO:0000250\|UniProtKB:Q86W26}.
Tissue specificity:		Expressed in skin, tongue, heart, colon and several cell lines of hematopoietic and myocytic origin but not in kidney, skeletal muscle, spleen, liver, lung, thymus, brain or small intestine (at protein level). {ECO:0000269\|PubMed:20393137}.
Domain:		The pyrin and ATP-binding domains are required to elicit cytokine release following bacterial infection. {ECO:0000250}.
Domain:		The NACHT domain is required for inhibition of CASP1 autoprocessing. {ECO:0000250}.
Disruption phenotype:		High susceptibility to systemic infection by C.albicans with 100% mortality by day 16 post-infection (PubMed:23071280). Does not alter Nlrp3 inflammasome activity and up- regulates Gdpd3 expression (PubMed:22538615). Does not impair skin repair after wounding (PubMed:27221772). Also does not impair the irritant contact dermatitis response following treatment with the irritant croton oil (PubMed:27221772). Significantly reduced inflammation in dinitrofluorobenzene-induced contact hypersensitivity response with reduced numbers of CD3(+), CD8(+) and CD4(+) T cells (PubMed:27221772). {ECO:0000269\|PubMed:22538615, ECO:0000269\|PubMed:23071280, ECO:0000269\|PubMed:27221772}.
Similarity:		Belongs to the NLRP family. {ECO:0000305}.