UniProt functional annotation for Q9QYE9



	UniProt functional annotation for Q9QYE9

UniProt code: Q9QYE9.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Subunit: Binds transducins (By similarity). Homodimer. Interacts (via PH domain) with MYO1C. Interacts (via PH domain) with MYO7A. {ECO:0000250|UniProtKB:Q9UF11, ECO:0000269|PubMed:15976448}.

Subcellular location: Membrane {ECO:0000269|PubMed:20301200}. Cytoplasm {ECO:0000269|PubMed:20301200}. Note=Membrane-associated. Highly expressed in the outer segments of photoreceptor cells, both in rods and cones (By similarity). Localizes to the apical juxta-nuclear Golgi region of the cytoplasm (PubMed:20301200). {ECO:0000250|UniProtKB:Q9UF11}.

Tissue specificity: Highly expressed in retina and brain. In retina, abundantly expressed in photoreceptors. Isoform 4 is the predominant isoform expressed in mature olfactory receptor neurons and vestibular and cochlear hair cells. Also expressed in cells with possible sensory function, including peripheral retinal ganglion cells, cochlear interdental cells, and neurons of the circumventricular organ (at protein level). {ECO:0000269|PubMed:10585447, ECO:0000269|PubMed:15456885, ECO:0000269|PubMed:20301200}.

Disruption phenotype: Mice appear normal at birth with no obvious behavioral or growth abnormalities nor overt sensory deficits. At 6 months and 1 year of age, mice display normal retinal histology and normal response in electroretinograms. {ECO:0000269|PubMed:15456885}.

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.


Subunit:		Binds transducins (By similarity). Homodimer. Interacts (via PH domain) with MYO1C. Interacts (via PH domain) with MYO7A. {ECO:0000250\|UniProtKB:Q9UF11, ECO:0000269\|PubMed:15976448}.
Subcellular location:		Membrane {ECO:0000269\|PubMed:20301200}. Cytoplasm {ECO:0000269\|PubMed:20301200}. Note=Membrane-associated. Highly expressed in the outer segments of photoreceptor cells, both in rods and cones (By similarity). Localizes to the apical juxta-nuclear Golgi region of the cytoplasm (PubMed:20301200). {ECO:0000250\|UniProtKB:Q9UF11}.
Tissue specificity:		Highly expressed in retina and brain. In retina, abundantly expressed in photoreceptors. Isoform 4 is the predominant isoform expressed in mature olfactory receptor neurons and vestibular and cochlear hair cells. Also expressed in cells with possible sensory function, including peripheral retinal ganglion cells, cochlear interdental cells, and neurons of the circumventricular organ (at protein level). {ECO:0000269\|PubMed:10585447, ECO:0000269\|PubMed:15456885, ECO:0000269\|PubMed:20301200}.
Disruption phenotype:		Mice appear normal at birth with no obvious behavioral or growth abnormalities nor overt sensory deficits. At 6 months and 1 year of age, mice display normal retinal histology and normal response in electroretinograms. {ECO:0000269\|PubMed:15456885}.