|
|
||
|
|
|
|
|
UniProt functional annotation for Q9BU19 | ||
|
|
|
|
|
|
||
| UniProt code: Q9BU19. |
|
||
| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
|
||
|
||
| Function: | |
May act as an transcriptional repressor for PCK1 gene expression, in turn may participate in the hepatic gluconeogenesis regulation through the activated AMPK signaling pathway. {ECO:0000269|PubMed:17097062, ECO:0000269|PubMed:21910974}. |
|
||
| Subcellular location: | |
Nucleus {ECO:0000305}. |
| Tissue specificity: | |
Ubiquitous (PubMed:17097062). Highly expressed in brain, thymus and spleen (PubMed:17097062). {ECO:0000269|PubMed:17097062}. |
| Ptm: | |
Phosphorylation at Ser-470 results in loss of DNA-binding activity. {ECO:0000269|PubMed:17097062}. |
| Similarity: | |
Belongs to the krueppel C2H2-type zinc-finger protein family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.