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UniProt functional annotation for O00241 | ||
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| UniProt code: O00241. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK. Triggers activation of myeloid cells when associated with TYROBP (PubMed:10604985). {ECO:0000269|PubMed:10604985}. |
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| Subunit: | |
Homodimer; disulfide-linked. Interacts with TYROBP. This interaction results in the recruitment of SYK. {ECO:0000269|PubMed:10604985, ECO:0000269|PubMed:10940905, ECO:0000269|PubMed:16081415, ECO:0000269|PubMed:18657508}. |
| Subcellular location: | |
Cell membrane {ECO:0000269|PubMed:10604985}; Single-pass type I membrane protein {ECO:0000255}. |
| Tissue specificity: | |
Detected in monocytes and dendritic cells. {ECO:0000269|PubMed:10604985}. |
| Ptm: | |
N-glycosylated. {ECO:0000269|PubMed:10604985, ECO:0000269|PubMed:16335952}. |
Annotations taken from UniProtKB at the EBI.