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UniProt functional annotation for A6NI73 | ||
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| UniProt code: A6NI73. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
May play a role in triggering innate immune responses. Does not seem to play a role for any class I MHC antigen recognition. {ECO:0000269|PubMed:16675463}. |
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| Subcellular location: | |
Cell membrane {ECO:0000269|PubMed:12393390}; Single-pass type I membrane protein {ECO:0000255}. |
| Subcellular location: | |
[Isoform 3]: Secreted {ECO:0000269|PubMed:12393390}. |
| Tissue specificity: | |
Expressed mostly in tissues of the hematopoietic system, including bone marrow, spleen, lymph node and peripheral leukocytes. Among leukocytes, monocytes and neutrophils express the highest level. Expressed in CD14+ monocytes, but not in T-cells, B- cells or natural killer (NK) cells (at protein level). {ECO:0000269|PubMed:12393390}. |
Annotations taken from UniProtKB at the EBI.