UniProt functional annotation for Q15642



	UniProt functional annotation for Q15642

UniProt code: Q15642.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5- bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte- derived cells. May be required for the lysosomal retention of FASLG/FASL. {ECO:0000250, ECO:0000269|PubMed:11069762, ECO:0000269|PubMed:16318909, ECO:0000269|PubMed:16326391}.

Subunit: Interacts specifically with GTP-bound RHOQ. Interacts with DNM2 and PDE6G (By similarity). Homodimerizes, the dimers can polymerize end-to-end to form filamentous structures. Interacts specifically with GTP-bound CDC42. Interacts with AKAP9, ARHGAP17, DAAM1, DIAPH1, DIAPH2, DNM1, FASLG/FASL, GAPVD1, LYN, microtubules, SRC, WAS/WASP and WASL/N-WASP. Interacts with the ligand binding domain of the thyroid receptor (TR) in the presence of thyroid hormone. May interact with CTNNB1 and HD/HTT. {ECO:0000250, ECO:0000269|PubMed:10713100, ECO:0000269|PubMed:11431473, ECO:0000269|PubMed:12456510, ECO:0000269|PubMed:12604778, ECO:0000269|PubMed:15047863, ECO:0000269|PubMed:16318909, ECO:0000269|PubMed:16326391, ECO:0000269|PubMed:16343437, ECO:0000269|PubMed:16630611, ECO:0000269|PubMed:17512409, ECO:0000269|PubMed:9210375}.

Subcellular location: Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Lysosome. Golgi apparatus. Cell membrane. Cell projection, phagocytic cup. Note=Translocates to the plasma membrane in response to insulin stimulation, and this may require active RHOQ (By similarity). Localizes to cortical regions coincident with F-actin, to lysosomes and to sites of phagocytosis in macrophages. Also localizes to the Golgi, and this requires AKAP9. {ECO:0000250}.

Subcellular location: [Isoform 5]: Cytoplasm, perinuclear region.

Tissue specificity: Expressed in brain, colon, heart, kidney, liver, lung, megakaryocyte, ovary, pancreas, peripheral blood lymphocytes, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus and trachea. {ECO:0000269|PubMed:11294612, ECO:0000269|PubMed:12054674, ECO:0000269|PubMed:12456510, ECO:0000269|PubMed:12604778, ECO:0000269|PubMed:9210375}.

Induction: Induced by adriamycin treatment and this effect is counteracted by HGF/SF. Expression is reduced during differentiation. {ECO:0000269|PubMed:11691828, ECO:0000269|PubMed:12054674}.

Domain: The F-BAR domain binds the phospholipid membrane with its concave surface. The end-to-end polymerization of dimers of these domains provides a curved surface that fits best membranes with around 600 A diameter, and may drive tubulation. {ECO:0000269|PubMed:17512409}.

Ptm: Tyrosine phosphorylated. Also phosphorylated by PKA. {ECO:0000269|PubMed:12456510, ECO:0000269|PubMed:15047863, ECO:0000269|PubMed:16343437}.

Similarity: Belongs to the FNBP1 family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5- bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte- derived cells. May be required for the lysosomal retention of FASLG/FASL. {ECO:0000250, ECO:0000269\|PubMed:11069762, ECO:0000269\|PubMed:16318909, ECO:0000269\|PubMed:16326391}.


Subunit:		Interacts specifically with GTP-bound RHOQ. Interacts with DNM2 and PDE6G (By similarity). Homodimerizes, the dimers can polymerize end-to-end to form filamentous structures. Interacts specifically with GTP-bound CDC42. Interacts with AKAP9, ARHGAP17, DAAM1, DIAPH1, DIAPH2, DNM1, FASLG/FASL, GAPVD1, LYN, microtubules, SRC, WAS/WASP and WASL/N-WASP. Interacts with the ligand binding domain of the thyroid receptor (TR) in the presence of thyroid hormone. May interact with CTNNB1 and HD/HTT. {ECO:0000250, ECO:0000269\|PubMed:10713100, ECO:0000269\|PubMed:11431473, ECO:0000269\|PubMed:12456510, ECO:0000269\|PubMed:12604778, ECO:0000269\|PubMed:15047863, ECO:0000269\|PubMed:16318909, ECO:0000269\|PubMed:16326391, ECO:0000269\|PubMed:16343437, ECO:0000269\|PubMed:16630611, ECO:0000269\|PubMed:17512409, ECO:0000269\|PubMed:9210375}.
Subcellular location:		Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Lysosome. Golgi apparatus. Cell membrane. Cell projection, phagocytic cup. Note=Translocates to the plasma membrane in response to insulin stimulation, and this may require active RHOQ (By similarity). Localizes to cortical regions coincident with F-actin, to lysosomes and to sites of phagocytosis in macrophages. Also localizes to the Golgi, and this requires AKAP9. {ECO:0000250}.
Subcellular location:		[Isoform 5]: Cytoplasm, perinuclear region.
Tissue specificity:		Expressed in brain, colon, heart, kidney, liver, lung, megakaryocyte, ovary, pancreas, peripheral blood lymphocytes, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus and trachea. {ECO:0000269\|PubMed:11294612, ECO:0000269\|PubMed:12054674, ECO:0000269\|PubMed:12456510, ECO:0000269\|PubMed:12604778, ECO:0000269\|PubMed:9210375}.
Induction:		Induced by adriamycin treatment and this effect is counteracted by HGF/SF. Expression is reduced during differentiation. {ECO:0000269\|PubMed:11691828, ECO:0000269\|PubMed:12054674}.
Domain:		The F-BAR domain binds the phospholipid membrane with its concave surface. The end-to-end polymerization of dimers of these domains provides a curved surface that fits best membranes with around 600 A diameter, and may drive tubulation. {ECO:0000269\|PubMed:17512409}.
Ptm:		Tyrosine phosphorylated. Also phosphorylated by PKA. {ECO:0000269\|PubMed:12456510, ECO:0000269\|PubMed:15047863, ECO:0000269\|PubMed:16343437}.
Similarity:		Belongs to the FNBP1 family. {ECO:0000305}.