PDBsum entry 2ct2

Ligase

PDB id: 2ct2

Contents

Protein chain

88 a.a. *

Metals

_ZN ×2

* Residue conservation analysis

PDB id:

2ct2

Name:

Ligase

Title:

Solution structure of the ring domain of the tripartite motif protein 32

Structure:

Tripartite motif protein 32. Chain: a. Fragment: ring domain. Synonym: zinc-finger protein ht2a, 72 kda tat-interacting protein. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: trim32. Other_details: cell-free protein synthesis

NMR struc:

20 models

Authors:

K.Miyamoto,N.Tochio,M.Sato,S.Koshiba,M.Inoue,T.Kigawa,S.Yokoyama, Riken Structural Genomics/proteomics Initiative (Rsgi)

Key ref:

K.Miyamoto et al. Solution structure of the ring domain of the tripartite motif protein 32. To be published, .

Date:

23-May-05 Release date: 23-Nov-05

Protein chain

Q13049  (TRI32_HUMAN) -  E3 ubiquitin-protein ligase TRIM32 from Homo sapiens

Seq: 653 a.a.

Struc: 88 a.a.*

* PDB and UniProt seqs differ at 11 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.3.2.27 - RING-type E3 ubiquitin transferase.
• Reaction: S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N₆- ubiquitinyl-[acceptor protein]-L-lysine