PDBsum entry 2cr3

Cytokine

PDB id: 2cr3

Contents

Protein chain

99 a.a. *

* Residue conservation analysis

PDB id:

2cr3

Name:

Cytokine

Title:

Solution structure of the first ig-like domain of human fibroblast growth factor receptor 1

Structure:

Basic fibroblast growth factor receptor 1. Chain: a. Fragment: ig domain. Synonym: fgfr-1, bfgf-r, fms-like tyrosine kinase-2, c-fgr. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: fgfr1. Other_details: cell free protein synthesis

NMR struc:

20 models

Authors:

R.Hatta,F.Hayashi,M.Yoshida,S.Yokoyama,Riken Structural Genomics/proteomics Initiative (Rsgi)

Key ref:

R.Hatta et al. Solution structure of the first ig-Like domain of human fibroblast growth factor receptor 1. To be published, .

Date:

20-May-05 Release date: 20-Nov-05

Protein chain

P11362  (FGFR1_HUMAN) -  Fibroblast growth factor receptor 1 from Homo sapiens

Seq: 822 a.a.

Struc: 99 a.a.*

* PDB and UniProt seqs differ at 12 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.7.10.1 - receptor protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site