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PDBsum entry 2cnq

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protein ligands metals links
Ligase PDB id
2cnq
Jmol PyMol
Contents
Protein chain
302 a.a. *
Ligands
ADP ×2
AMZ ×2
AMP
SIN ×2
SO4 ×4
Metals
_MG
Waters ×733
* Residue conservation analysis
PDB id:
2cnq
Name: Ligase
Title: Atomic resolution structure of saicar-synthase from saccharomyces cerevisiae complexed with adp, aicar, succinate
Structure: Phosphoribosylaminoimidazole-succinocarboxamide synthase. Chain: a. Synonym: saicar synthetase. Ec: 6.3.2.6
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932
Resolution:
1.00Å     R-factor:   0.116     R-free:   0.130
Authors: D.V.Urusova,S.V.Antonyuk,A.I.Grebenko,V.M.Levdikov, V.V.Barynin,A.N.Popov,V.S.Lamzin,W.R.Melik-Adamyan
Key ref: D.V.Urusova et al. Saicar synthase: substrate recognition, Conformational flexibility and catalysis.. To be published, .
Date:
23-May-06     Release date:   08-Jun-06    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P27616  (PUR7_YEAST) -  Phosphoribosylaminoimidazole-succinocarboxamide synthase
Seq:
Struc:
306 a.a.
301 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.6.3.2.6  - Phosphoribosylaminoimidazolesuccinocarboxamide synthase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
Purine Biosynthesis (late stages)
      Reaction: ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamido)succinate
ATP
+
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
Bound ligand (Het Group name = AMZ)
matches with 91.00% similarity
+
L-aspartate
Bound ligand (Het Group name = SIN)
matches with 88.00% similarity
=
ADP
Bound ligand (Het Group name = ADP)
corresponds exactly
+ phosphate
+ (S)-2-(5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamido)succinate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     purine nucleotide biosynthetic process   2 terms 
  Biochemical function     nucleotide binding     5 terms  

 

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