UniProt functional annotation for Q9JIS1



	UniProt functional annotation for Q9JIS1

UniProt code: Q9JIS1.

Organism: Rattus norvegicus (Rat).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus.

Function: Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (By similarity). {ECO:0000250|UniProtKB:Q9UQ26}.

Subunit: Heterodimer with PCLO. Part of a ternary complex involving PCLO and EPAC2. Interacts with RAB3C, RAB3D and RAB26 (By similarity). Binds RAB3A and RAB3B that have been activated by GTP-binding. Interacts with TSPOAP1 and RIMBP2. Interacts with PPFIA3 and PPFIA4. Interacts via its zinc finger with the first C2 domain of UNC13A. Forms a complex consisting of UNC13A, RIMS2 and RAB3A. {ECO:0000250, ECO:0000269|PubMed:10748113, ECO:0000269|PubMed:11797009, ECO:0000269|PubMed:16052212, ECO:0000269|PubMed:16732694}.

Subcellular location: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cell junction, synapse, presynaptic cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Tissue specificity: Highly expressed in hippocampus, brain cortex, cerebellum and olfactory bulb. Detected at intermediate levels in midbrain, hindbrain and spinal cord, and at low levels in testis. {ECO:0000269|PubMed:10748113}.

Annotations taken from UniProtKB at the EBI.


Organism:		Rattus norvegicus (Rat).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus.



Function:		Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (By similarity). {ECO:0000250\|UniProtKB:Q9UQ26}.


Subunit:		Heterodimer with PCLO. Part of a ternary complex involving PCLO and EPAC2. Interacts with RAB3C, RAB3D and RAB26 (By similarity). Binds RAB3A and RAB3B that have been activated by GTP-binding. Interacts with TSPOAP1 and RIMBP2. Interacts with PPFIA3 and PPFIA4. Interacts via its zinc finger with the first C2 domain of UNC13A. Forms a complex consisting of UNC13A, RIMS2 and RAB3A. {ECO:0000250, ECO:0000269\|PubMed:10748113, ECO:0000269\|PubMed:11797009, ECO:0000269\|PubMed:16052212, ECO:0000269\|PubMed:16732694}.
Subcellular location:		Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cell junction, synapse, presynaptic cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Tissue specificity:		Highly expressed in hippocampus, brain cortex, cerebellum and olfactory bulb. Detected at intermediate levels in midbrain, hindbrain and spinal cord, and at low levels in testis. {ECO:0000269\|PubMed:10748113}.