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UniProt functional annotation for Q9UJ41 | ||
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| UniProt code: Q9UJ41. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity). {ECO:0000250, ECO:0000269|PubMed:11452015, ECO:0000269|PubMed:15339665, ECO:0000269|PubMed:9323142}. |
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| Subunit: | |
Interacts with RGS14; the interaction is GTP-dependent (By similarity). Heterodimer with RABEP1. The heterodimer binds RAB4A and RAB5A that have been activated by GTP-binding. Interacts with RAB21, and with 100-fold lower affinity also with RAB22. Binds TSC2, GGA1, GGA2, GGA3, AP1G1 and AP1G2. Interacts with ubiquitinated EGFR. {ECO:0000250, ECO:0000269|PubMed:11452015, ECO:0000269|PubMed:12505986, ECO:0000269|PubMed:15339665, ECO:0000269|PubMed:16499958, ECO:0000269|PubMed:17450153, ECO:0000269|PubMed:9323142}. |
| Subcellular location: | |
Cytoplasm {ECO:0000269|PubMed:12505986}. Early endosome {ECO:0000269|PubMed:12505986}. Recycling endosome {ECO:0000269|PubMed:12505986}. |
| Ptm: | |
Monoubiquitinated. |
| Sequence caution: | |
Sequence=BAC87138.1; Type=Miscellaneous discrepancy; Note=Readthrough transcript KCTD7-RABGEF1.; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.