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UniProt functional annotation for Q59643 | ||
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| UniProt code: Q59643. |
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| Organism: | |
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas. |
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| Function: | |
Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity). {ECO:0000250}. |
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| Catalytic activity: | |
Reaction=2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen; Xref=Rhea:RHEA:24064, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58126, ChEBI:CHEBI:356416; EC=4.2.1.24; Evidence={ECO:0000269|PubMed:16819823}; |
| Cofactor: | |
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:12079382, ECO:0000269|PubMed:16819823}; |
| Activity regulation: | |
Stimulated by magnesium ions. |
| Pathway: | |
Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4. |
| Subunit: | |
Homooctamer; formed by oligomerization of dimers. {ECO:0000269|PubMed:10356331, ECO:0000269|PubMed:12079382, ECO:0000269|PubMed:19822707}. |
| Similarity: | |
Belongs to the ALAD family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.