 |
PDBsum entry 2bz6
|
|
|
|
References listed in PDB file
|
 |
|
Key reference
|
|
|
Title
|
|
Dose-Dependent antithrombotic activity of an orally active tissue factor/factor viia inhibitor without concomitant enhancement of bleeding propensity.
|
|
|
Authors
|
|
K.Groebke zbinden,
D.W.Banner,
K.Hilpert,
J.Himber,
T.Lavé,
M.A.Riederer,
M.Stahl,
T.B.Tschopp,
U.Obst-Sander.
|
|
|
Ref.
|
|
Bioorg Med Chem Lett, 2006,
14,
5357-5369.
|
|
|
PubMed id
|
|
|
|
|
|
Abstract
|
|
|
The discovery of a highly potent and selective tissue factor/factor VIIa
inhibitor is described. Upon oral administration of its double prodrug in the
guinea pig, a dose-dependent antithrombotic effect is observed in an established
model of arterial thrombosis without prolonging bleeding time. The
pharmacodynamic properties of this selective inhibitor are compared to the
behaviour of a mixed factor VIIa/factor Xa inhibitor.
|
|
|
|
|
|
|
