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UniProt functional annotation for Q62230 | ||
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| UniProt code: Q62230. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells (By similarity). Preferentially binds to alpha-2,3-linked sialic acid. Binds to SPN/CD43 on T-cells. May play a role in hematopoiesis. May act as a counter-receptor for CLEC10A in lymph node. {ECO:0000250, ECO:0000269|PubMed:15364954}. |
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| Subunit: | |
Interacts with CLEC10A. {ECO:0000269|PubMed:11238599, ECO:0000269|PubMed:12737821, ECO:0000269|PubMed:15364954, ECO:0000269|PubMed:15488769, ECO:0000269|PubMed:9660955}. |
| Subcellular location: | |
[Isoform 1]: Cell membrane; Single-pass type I membrane protein. |
| Subcellular location: | |
[Isoform 2]: Secreted. |
| Subcellular location: | |
[Isoform 3]: Secreted. |
| Tissue specificity: | |
Detected in lymph node in the subcapsular sinus, interfollicular regions, and T and B-cell boundary (at protein level). Expressed by macrophages in various tissues. Highest expression in spleen and lymph node with lower amounts in lung, liver, bone marrow, heart and skin. No expression in thymus, kidney, brain or small intestine. {ECO:0000269|PubMed:15364954}. |
| Similarity: | |
Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. {ECO:0000305}. |
| Sequence caution: | |
Sequence=CAA85268.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=CAA85290.1; Type=Frameshift; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.