UniProt functional annotation for Q08116



	UniProt functional annotation for Q08116

UniProt code: Q08116.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors (PubMed:10480894). Inhibits B cell chemotaxis toward CXCL12 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form (PubMed:10480894, PubMed:18434541). {ECO:0000250|UniProtKB:Q9JL25, ECO:0000269|PubMed:10480894, ECO:0000269|PubMed:18434541}.

Subunit: Interacts with GNAI1 and GNAQ. {ECO:0000269|PubMed:18434541}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:10480894}; Peripheral membrane protein {ECO:0000269|PubMed:10480894}; Cytoplasmic side {ECO:0000269|PubMed:10480894}. Cytoplasm, cytosol {ECO:0000269|PubMed:10480894}.

Tissue specificity: Detected in peripheral blood monocytes (PubMed:10480894). Expression is relatively low in B-cells and chronic lymphocytic leukemia B-cells; however, in other types of malignant B- cell such as non-Hodgkin lymphoma and hairy cell leukemia, expression is constitutively high (PubMed:8473738). {ECO:0000269|PubMed:10480894, ECO:0000269|PubMed:8473738}.

Induction: In response to several B-cell activation signals. {ECO:0000269|PubMed:8473738}.

Sequence caution: Sequence=AAB26289.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH15510.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG37976.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG64242.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA51826.1; Type=Erroneous initiation; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors (PubMed:10480894). Inhibits B cell chemotaxis toward CXCL12 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form (PubMed:10480894, PubMed:18434541). {ECO:0000250\|UniProtKB:Q9JL25, ECO:0000269\|PubMed:10480894, ECO:0000269\|PubMed:18434541}.


Subunit:		Interacts with GNAI1 and GNAQ. {ECO:0000269\|PubMed:18434541}.
Subcellular location:		Cell membrane {ECO:0000269\|PubMed:10480894}; Peripheral membrane protein {ECO:0000269\|PubMed:10480894}; Cytoplasmic side {ECO:0000269\|PubMed:10480894}. Cytoplasm, cytosol {ECO:0000269\|PubMed:10480894}.
Tissue specificity:		Detected in peripheral blood monocytes (PubMed:10480894). Expression is relatively low in B-cells and chronic lymphocytic leukemia B-cells; however, in other types of malignant B- cell such as non-Hodgkin lymphoma and hairy cell leukemia, expression is constitutively high (PubMed:8473738). {ECO:0000269\|PubMed:10480894, ECO:0000269\|PubMed:8473738}.
Induction:		In response to several B-cell activation signals. {ECO:0000269\|PubMed:8473738}.
Sequence caution:		Sequence=AAB26289.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH15510.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG37976.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG64242.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA51826.1; Type=Erroneous initiation; Evidence={ECO:0000305};