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UniProt functional annotation for P13727 | ||
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| UniProt code: P13727. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA. {ECO:0000269|PubMed:10913121}. |
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| Subunit: | |
In pregnancy serum, the proform exists as a disulfide-linked 2:2 heterotetramer with PAPPA, as a disulfide-linked 2:2 heterotetramer with AGT, and as a complex (probably a 2:2:2 heterohexamer) with AGT and C3dg. {ECO:0000269|PubMed:10913121, ECO:0000269|PubMed:7508748, ECO:0000269|PubMed:7539791, ECO:0000269|PubMed:7685339, ECO:0000269|PubMed:8137941}. |
| Subcellular location: | |
[Bone marrow proteoglycan]: Secreted. Note=The proform is secreted. |
| Subcellular location: | |
[Eosinophil granule major basic protein]: Cytoplasmic vesicle, secretory vesicle. Note=The proform is secreted. The mature protein is found in the matrix of the eosinophil's large specific granule (crystalloid core). |
| Tissue specificity: | |
High levels of the proform in placenta and pregnancy serum; in placenta, localized to X cells of septa and anchoring villi. Lower levels in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow and colon. {ECO:0000269|PubMed:10491647, ECO:0000269|PubMed:7526035}. |
| Developmental stage: | |
Levels of the proform increase in serum and placenta during pregnancy. {ECO:0000269|PubMed:10491647, ECO:0000269|PubMed:7539791}. |
| Ptm: | |
Nitrated. {ECO:0000269|PubMed:18694936}. |
| Miscellaneous: | |
Binds heparin. Does not bind calcium. |
Annotations taken from UniProtKB at the EBI.