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UniProt functional annotation for Q14596 | ||
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| UniProt code: Q14596. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets. {ECO:0000269|PubMed:19250911}. |
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| Subunit: | |
Homooligomer and heterooligomer. Interacts with TRIM55 (By similarity). Interacts with SQSTM1, titin/TTN, RNF29, USP8, SQSTM1, MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2. Binds to ubiquitin and ubiquitinated proteins. {ECO:0000250, ECO:0000269|PubMed:12813044, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:19250911, ECO:0000269|PubMed:19427866}. |
| Subcellular location: | |
Cytoplasm {ECO:0000269|PubMed:19427866}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:19250911}. Lysosome {ECO:0000269|PubMed:19250911}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000250|UniProtKB:Q501R9}. Note=In cardiac muscles localizes to the sarcomeric M line (By similarity). Is targeted to lysosomes for degradation (PubMed:19250911). {ECO:0000250|UniProtKB:Q501R9, ECO:0000269|PubMed:19250911}. |
| Domain: | |
The PB1 domain mediates interaction with SQSTM1. {ECO:0000269|PubMed:12813044, ECO:0000269|PubMed:19250911}. |
| Sequence caution: | |
Sequence=BAA06417.2; Type=Erroneous initiation; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.