PDBsum entry 2bgd

Hydrolase

PDB id: 2bgd

Contents

Protein chain

295 a.a.

Ligands

T1D

PO4

Metals

_NA

_CL ×3

Waters ×174

References listed in PDB file

Key reference

• Title: Structure-Based design of protein tyrosine phosphatase-1b inhibitors.
• Authors: E.Black, J.Breed, A.L.Breeze, K.Embrey, R.Garcia, T.W.Gero, L.Godfrey, P.W.Kenny, A.D.Morley, C.A.Minshull, A.D.Pannifer, J.Read, A.Rees, D.J.Russell, D.Toader, J.Tucker.
• Ref.: Bioorg Med Chem Lett, 2005, 15, 2503-2507. [DOI no: 10.1016/j.bmcl.2005.03.068]
• PubMed id: 15863305

Abstract

Using structure-based design, a new class of inhibitors of protein tyrosine phosphatase-1B (PTP1B) has been identified, which incorporate the 1,2,5-thiadiazolidin-3-one-1,1-dioxide template.