PDBsum entry 2b86

Signaling protein

PDB id

2b86

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Contents

			Protein chain

					59 a.a. *

* Residue conservation analysis

PDB id:

2b86

Links
- PDBe
- RCSB
- MMDB
- JenaLib
- Proteopedia
- CATH
- SCOP
- PDBSWS
- ProSAT

Name:

Signaling protein

Title:

Solution structure of the first src homology 3 domain of nck2

Structure:

Cytoplasmic protein nck2. Chain: a. Fragment: first sh3 domain, residues 1-59. Synonym: nck adaptor protein 2, sh2/sh3 adaptor protein nck-beta, nck-2. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: nck2. Expressed in: escherichia coli. Expression_system_taxid: 562.

NMR struc:

30 models

Authors:

S.Park,K.Takeuchi,G.Wagner

Key ref:

S.Park et al. (2006). Solution structure of the first SRC homology 3 domain of human Nck2. J Biomol Nmr, 34, 203-208. PubMed id: 16604428

Date:

06-Oct-05

Release date:

09-May-06

PROCHECK

	Headers

	References

Protein chain

O43639 (NCK2_HUMAN) - Cytoplasmic protein NCK2 from Homo sapiens

Seq: Struc:					380 a.a. 59 a.a.

Key:

PfamA domain

Secondary structure

CATH domain



		Enzyme reactions

Enzyme class:

E.C.?

[IntEnz] [ExPASy] [KEGG] [BRENDA]

	J Biomol Nmr 34:203-208 (2006)
PubMed id: 16604428

Solution structure of the first SRC homology 3 domain of human Nck2.
S.Park, K.Takeuchi, G.Wagner.

ABSTRACT

No abstract given.

Literature references that cite this PDB file's key reference

PubMed id

Reference

19956763

J.Liu, and J.Song (2009).
Insights into protein aggregation by NMR characterization of insoluble SH3 mutants solubilized in salt-free water.

PLoS One, 4, e7805.

18599634

J.Liu, and J.Song (2008).
NMR evidence for forming highly populated helical conformations in the partially folded hNck2 SH3 domain.

Biophys J, 95, 4803-4812.

18555270

K.Takeuchi, H.Yang, E.Ng, S.Y.Park, Z.Y.Sun, E.L.Reinherz, and G.Wagner (2008).
Structural and functional evidence that Nck interaction with CD3epsilon regulates T-cell receptor activity.

J Mol Biol, 380, 704-716.

PDB code:

2jxb

19049287

K.Takeuchi, Z.Y.Sun, and G.Wagner (2008).
Alternate 13C-12C labeling for complete mainchain resonance assignments using C alpha direct-detection with applicability toward fast relaxing protein systems.

J Am Chem Soc, 130, 17210-17211.

17390105

K.Takeuchi, E.Ng, T.J.Malia, and G.Wagner (2007).
1-13C amino acid selective labeling in a 2H15N background for NMR studies of large proteins.

J Biomol NMR, 38, 89-98.

16980357

M.Li, J.Liu, X.Ran, M.Fang, J.Shi, H.Qin, J.M.Goh, and J.Song (2006).
Resurrecting abandoned proteins with pure water: CD and NMR studies of protein fragments solubilized in salt-free water.

Biophys J, 91, 4201-4209.

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB code is shown on the right.