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PDBsum entry 2b7d
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protein ligands Protein-protein interface(s) links
Blood clotting PDB id
2b7d

 

 

 

 

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JSmol PyMol  
Contents
Protein chains
94 a.a. *
254 a.a. *
149 a.a. *
Ligands
C1B
Waters ×306
* Residue conservation analysis
PDB id:
2b7d
Name: Blood clotting
Title: Factor viia inhibitors: chemical optimization, preclinical pharmacokinetics, pharmacodynamics, and efficacy in a baboon thrombosis model
Structure: Coagulation factor vii. Chain: l. Fragment: light chain. Synonym: serum prothrombin conversion accelerator, spca, proconvertin, eptacog alfa. Engineered: yes. Coagulation factor vii. Chain: h. Fragment: heavy chain.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek 293. Expression_system_atcc_number: crl-1573. Gene: f3.
Biol. unit: Trimer (from PQS)
Resolution:
2.24Å     R-factor:   0.247     R-free:   0.289
Authors: W.B.Young,J.Mordenti,S.Torkelson,W.D.Shrader,A.Kolesnikov,R.Rai, L.Liu,H.Hu,E.M.Leahy,M.J.Green,P.A.Sprengeler,B.A.Katz,C.Yu, J.W.Janc,K.C.Elrod,U.M.Marzec,S.R.Hanson
Key ref: W.B.Young et al. (2006). Factor VIIa inhibitors: chemical optimization, preclinical pharmacokinetics, pharmacodynamics, and efficacy in an arterial baboon thrombosis model. Bioorg Med Chem Lett, 16, 2037-2041. PubMed id: 16412633 DOI: 10.1016/j.bmcl.2005.12.059
Date:
04-Oct-05     Release date:   14-Feb-06    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
P08709  (FA7_HUMAN) -  Coagulation factor VII from Homo sapiens
Seq:
Struc: 		466 a.a.
94 a.a.
Protein chain
P08709  (FA7_HUMAN) -  Coagulation factor VII from Homo sapiens
Seq:
Struc: 		466 a.a.
254 a.a.
Protein chain
P13726  (TF_HUMAN) -  Tissue factor from Homo sapiens
Seq:
Struc: 		295 a.a.
149 a.a.
Key:    Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: Chains L, H: E.C.3.4.21.21  - coagulation factor VIIa.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Hydrolyzes one Arg-|-Ile bond in factor X to form factor Xa.

 

 
DOI no: 10.1016/j.bmcl.2005.12.059 Bioorg Med Chem Lett 16:2037-2041 (2006)
PubMed id: 16412633  
 
 
Factor VIIa inhibitors: chemical optimization, preclinical pharmacokinetics, pharmacodynamics, and efficacy in an arterial baboon thrombosis model.
W.B.Young, J.Mordenti, S.Torkelson, W.D.Shrader, A.Kolesnikov, R.Rai, L.Liu, H.Hu, E.M.Leahy, M.J.Green, P.A.Sprengeler, B.A.Katz, C.Yu, J.W.Janc, K.C.Elrod, U.M.Marzec, S.R.Hanson.
 
  ABSTRACT  
 
Highly selective and potent factor VIIa-tissue factor (fVIIa.TF) complex inhibitors were generated through structure-based design. The pharmacokinetic properties of an optimized analog (9) were characterized in several preclinical species, demonstrating pharmacokinetic characteristics suitable for once-a-day dosing in humans. Analog 9 inhibited platelet and fibrin deposition in a dose-dependent manner after intravenous administration in a baboon thrombosis model, and a pharmacodynamic concentration-response model was developed to describe the platelet deposition data. Results for heparin and enoxaparin (Lovenox) in the baboon model are also presented.
 

Literature references that cite this PDB file's key reference

  PubMed id Reference
20045964 T.Shiraishi, S.Kadono, M.Haramura, H.Kodama, Y.Ono, H.Iikura, T.Esaki, T.Koga, K.Hattori, Y.Watanabe, A.Sakamoto, K.Yoshihashi, T.Kitazawa, K.Esaki, M.Ohta, H.Sato, and T.Kozono (2010).
Design and synthesis of peptidomimetic factor VIIa inhibitors.
  Chem Pharm Bull (Tokyo), 58, 38-44.
PDB code: 2zzu
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB code is shown on the right.

 

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