PDBsum entry 2b53

Transferase

PDB id: 2b53

Contents

Protein chain

294 a.a.

Ligands

D23

Waters ×73

References listed in PDB file

Key reference

• Title: Quinazolines as cyclin dependent kinase inhibitors.
• Authors: T.M.Sielecki, T.L.Johnson, J.Liu, J.K.Muckelbauer, R.H.Grafstrom, S.Cox, J.Boylan, C.R.Burton, H.Chen, A.Smallwood, C.H.Chang, M.Boisclair, P.A.Benfield, G.L.Trainor, S.P.Seitz.
• Ref.: Bioorg Med Chem Lett, 2001, 11, 1157-1160. [DOI no: 10.1016/S0960-894X(01)00185-8]
• PubMed id: 11354366

Abstract

Quinazolines have been identified as inhibitors of CDK4/D1 and CDK2/E. Aspects of the SAR were investigated using solution-phase, parallel synthesis. An X-ray crystal structure was obtained of quinazoline 51 bound in CDK2 and key interactions within the ATP binding pocket are defined.