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UniProt functional annotation for P01491 | ||
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| UniProt code: P01491. |
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| Organism: | |
Centruroides sculpturatus (Arizona bark scorpion). |
| Taxonomy: | |
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Scorpiones; Buthida; Buthoidea; Buthidae; Centruroides. |
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| Function: | |
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. Affects channels from chicken and frog. |
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| Subcellular location: | |
Secreted. |
| Tissue specificity: | |
Expressed by the venom gland. |
| Domain: | |
Has the structural arrangement of an alpha-helix connected to antiparallel beta-sheets by disulfide bonds (CS-alpha/beta). {ECO:0000305}. |
| Similarity: | |
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.