 |
PDBsum entry 2b1p
|
|
|
|
References listed in PDB file
|
 |
|
Key reference
|
|
|
Title
|
|
Design and synthesis of 6-Anilinoindazoles as selective inhibitors of c-Jun n-Terminal kinase-3.
|
|
|
Authors
|
|
B.M.Swahn,
F.Huerta,
E.Kallin,
J.Malmström,
T.Weigelt,
J.Viklund,
P.Womack,
Y.Xue,
L.Ohberg.
|
|
|
Ref.
|
|
Bioorg Med Chem Lett, 2005,
15,
5095-5099.
|
|
|
PubMed id
|
|
|
|
|
|
Abstract
|
|
|
The structure-based design and synthesis of a new series of c-Jun N-terminal
kinase-3 inhibitors with selectivity against JNK1 and p38alpha is reported. The
novel series of substituted 6-anilinoindazoles were designed based on a
combination of hits from high throughput screening and X-ray crystal structure
information of the compounds crystallized into the JNK3 ATP binding active site.
|
|
|
|
|
|
|
