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UniProt functional annotation for P04553 | ||
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| UniProt code: P04553. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex. |
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| Subunit: | |
Cross-linked by interchain disulfide bonds around the DNA- helix. |
| Subcellular location: | |
Nucleus. Chromosome. |
| Tissue specificity: | |
Testis. |
| Ptm: | |
Phosphorylated by SRPK1. {ECO:0000269|PubMed:10390541}. |
| Similarity: | |
Belongs to the protamine P1 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.