UniProt functional annotation for Q14318

UniProt codes: Q14318, Q53GU3.

Organism: Homo sapiens (Human).
Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Function: Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. {ECO:0000269|PubMed:12510191, ECO:0000269|PubMed:15757646, ECO:0000269|PubMed:16176796}.
Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0). {ECO:0000269|PubMed:15990872}.
Cofactor: Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000269|PubMed:15990872};
Subunit: Homomultimers or heteromultimers (Potential). Forms heterodimer with calmodulin. When activated by calmodulin and calcium, interacts with the BH4 domain of BCL2 and weakly with BCL2L1/BCLX isoform Bcl-X(L). Does not bind and inhibit calcineurin. Interacts with HCV NS5A. Interacts with ZFYVE27; may negatively regulate ZFYVE27 phosphorylation. {ECO:0000269|PubMed:12510191, ECO:0000269|PubMed:15733859, ECO:0000269|PubMed:16844119, ECO:0000269|PubMed:17090549, ECO:0000269|PubMed:18385096, ECO:0000269|PubMed:18459960, ECO:0000305}.
Subcellular location: Isoform 1: Mitochondrion membrane; Single- pass membrane protein; Cytoplasmic side.
Subcellular location: Isoform 3: Mitochondrion membrane; Single- pass membrane protein; Cytoplasmic side.
Tissue specificity: Widely expressed. Highest levels seen in the brain. Highly abundant in the retina. {ECO:0000269|PubMed:18385096}.
Miscellaneous: Binds the immunosuppressant FK506 only in its calmodulin/calcium activated form.
Similarity: Contains 1 PPIase FKBP-type domain. {ECO:0000255|PROSITE-ProRule:PRU00277}.
Similarity: Contains 3 TPR repeats. {ECO:0000255|PROSITE- ProRule:PRU00339}.
Sequence caution: Sequence=AAB00102.1; Type=Miscellaneous discrepancy; Note=The first part of the cDNA maps to the same locus, but in opposite orientation.; Evidence={ECO:0000305}; Sequence=AAH09966.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAD98028.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.