PDBsum entry 2arw

Cytokine

PDB id: 2arw

Contents

Protein chain

103 a.a. *

* Residue conservation analysis

PDB id:

2arw

Name:

Cytokine

Title:

The solution structure of the membrane proximal cytokine receptor domain of the human interleukin-6 receptor

Structure:

Interleukin-6 receptor alpha chain. Chain: a. Fragment: third extracellular domain. Synonym: il-6r-alpha, il-6r 1, cd126 antigen. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.

NMR struc:

1 models

Authors:

O.Hecht,A.J.Dingley,A.Schwantner,S.Ozbek,S.Rose-John,J.Grotzinger

Key ref:

O.Hecht et al. (2006). The solution structure of the membrane-proximal cytokine receptor domain of the human interleukin-6 receptor. Biol Chem, 387, 1255-1259. PubMed id: 16972794

Date:

22-Aug-05 Release date: 12-Sep-06

Protein chain

P08887  (IL6RA_HUMAN) -  Interleukin-6 receptor subunit alpha from Homo sapiens

Seq: 468 a.a.

Struc: 103 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.?

Biol Chem 387:1255-1259 (2006)

PubMed id: 16972794

The solution structure of the membrane-proximal cytokine receptor domain of the human interleukin-6 receptor.

O.Hecht, A.J.Dingley, A.Schwanter, S.Ozbek, S.Rose-John, J.Grötzinger.

ABSTRACT

The members of the interleukin-6-type family of cytokines interact with receptors that have a modular structure and are built of several immunoglobulin-like and fibronectin type III-like domains. These receptors have a characteristic cytokine receptor homology region consisting of two fibronectin type III-like domains defined by a set of four conserved cysteines and a tryptophan-serine-X-tryptophan-serine sequence motif. On target cells, interleukin-6 (IL-6) initially binds to its cognate alpha-receptor and subsequently to a homodimer of the signal transducer receptor gp130. The IL-6 receptor (IL-6R) consists of three extracellular domains. The N-terminal immunoglobulin-like domain is not involved in ligand binding, whereas the third membrane-proximal fibronectin-like domain (IL-6R-D3) accounts for more than 90% of the binding energy to IL-6. Here, we present the solution structure of the IL-6R-D3 domain solved by multidimensional heteronuclear NMR spectroscopy.