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UniProt functional annotation for P0C1H3 | ||
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| UniProt code: P0C1H3. |
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| Organism: | |
Gallus gallus (Chicken). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus. |
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| Function: | |
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. {ECO:0000269|PubMed:16389069}. |
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| Function: | |
Has broad-spectrum antibacterial activity. May be important in the antimicrobial defenses of chick reproductive system during follicle development in the ovary and egg formation in the oviduct. {ECO:0000269|PubMed:16389069}. |
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| Subunit: | |
The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. |
| Subcellular location: | |
Nucleus. Chromosome. |
| Ptm: | |
Monoubiquitination of Lys-121 by the BRE1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. {ECO:0000250|UniProtKB:P33778}. |
| Ptm: | |
Phosphorylated on Ser-15 during apoptosis; which facilitates apoptotic chromatin condensation. {ECO:0000269|PubMed:12757711}. |
| Similarity: | |
Belongs to the histone H2B family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.