UniProt functional annotation for P61823

UniProt code: P61823.

Organism: Bos taurus (Bovine).
Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.
Function: Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA. {ECO:0000269|PubMed:7479688}.
Catalytic activity: Endonucleolytic cleavage to nucleoside 3'- phosphates and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates.
Subunit: Interacts with and forms tight 1:1 complexes with RNH1. Dimerization of two such complexes may occur. Interaction with RNH1 inhibits this protein (By similarity). Monomer. {ECO:0000250, ECO:0000269|PubMed:11513604}.
Subcellular location: Secreted.
Tissue specificity: Pancreas.
Miscellaneous: Ribonuclease can destabilize or unwind the DNA helix by complexing with single-stranded DNA; this complex arises by an extended multisite cation-anion interaction between the lysine and arginine residues of the enzyme and the phosphate groups of the nucleotides.
Similarity: Belongs to the pancreatic ribonuclease family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.