PDBsum entry 2ao7

Hydrolase

PDB id: 2ao7

Contents

Protein chain

146 a.a.

Ligands

SO4 ×2

References listed in PDB file

Key reference

• Title: Adam and eph: how ephrin-Signaling cells become detached.
• Authors: F.Mancia, L.Shapiro.
• Ref.: Cell, 2005, 123, 185-187. [DOI no: 10.1016/j.cell.2005.10.004]
• PubMed id: 16239135

Abstract

Ephrin ligands presented on one cell surface associate with their receptors on the surface of a juxtaposed cell, often resulting in cell-cell repulsion. In this issue of Cell, Janes et al. (2005) show that the ephrin ligand can be proteolytically released from its membrane tether by a complex on the opposing cell composed of the ephrin receptor and an ADAM metalloprotease.

Figure 1.
Figure 1. The Association between the ADAM10 Protease and the Ephrin-A5/EphA3 Ligand-Receptor Signaling Complex

The above figure is reprinted by permission from Cell Press: Cell (2005, 123, 185-187) copyright 2005.