|
|
||
|
|
|
|
|
UniProt functional annotation for P30101 | ||
|
|
|
|
|
|
||
| UniProt code: P30101. |
|
||
| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
|
||
| Catalytic activity: | |
Reaction=Catalyzes the rearrangement of -S-S- bonds in proteins.; EC=5.3.4.1; Evidence={ECO:0000269|PubMed:7487104}; |
| Subunit: | |
Subunit of the TAP complex, also known as the peptide loading complex (PLC). Can form disulfide-linked heterodimers with TAPBP. Interacts with ERP27 and CANX. Interacts with SERPINA2 and with the S and Z variants of SERPINA1. Interacts with ATP2A2. {ECO:0000250|UniProtKB:P27773, ECO:0000269|PubMed:16905107, ECO:0000269|PubMed:16940051, ECO:0000269|PubMed:19119025, ECO:0000269|PubMed:23826168}. |
| Subcellular location: | |
Endoplasmic reticulum {ECO:0000269|PubMed:23826168}. Endoplasmic reticulum lumen {ECO:0000250}. Melanosome {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545). {ECO:0000269|PubMed:12643545}. |
| Tissue specificity: | |
Detected in the flagellum and head region of spermatozoa (at protein level) (PubMed:20400973). Expressed in liver, stomach and colon (at protein level). Expressed in gastric parietal cells and chief cells (at protein level) (PubMed:24188822). {ECO:0000269|PubMed:20400973, ECO:0000269|PubMed:24188822}. |
| Mass spectrometry: | |
Mass=54265.22; Method=MALDI; Evidence={ECO:0000269|PubMed:11840567}; |
| Similarity: | |
Belongs to the protein disulfide isomerase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.