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UniProt functional annotation for P21575 | ||
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| UniProt code: P21575. |
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| Organism: | |
Rattus norvegicus (Rat). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. |
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| Function: | |
Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis (By similarity). {ECO:0000250}. |
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| Catalytic activity: | |
Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.5; |
| Subunit: | |
Interacts with CAV1 and SH3GLB1. Interacts with SNX9. Interacts with SNX33 (via SH3 domain) (By similarity). Interacts with PHOCN. Interacts with PACSIN1, PACSIN2 and PACSIN3 (By similarity). Binds SH3GL1, SH3GL2 and SH3GL3. Interacts with MYO1E (via SH3 domain). Interacts with UNC119; leading to a decrease of DNM1 GTPase activity (By similarity). Interacts with DIAPH1 (By similarity). Interacts with AMPH, BIN1 AND SYNJ1 (PubMed:9341169). {ECO:0000250|UniProtKB:Q05193, ECO:0000269|PubMed:9341169}. |
| Subcellular location: | |
Cytoplasm {ECO:0000269|PubMed:9725914}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9725914}. Note=Microtubule- associated (PubMed:9725914). Isoform-specific localization (PubMed:9725914). {ECO:0000269|PubMed:9725914}. |
| Subcellular location: | |
[Isoform 2]: Cytoplasm {ECO:0000269|PubMed:9725914}. |
| Subcellular location: | |
[Isoform 6]: Cytoplasm. Golgi apparatus {ECO:0000269|PubMed:9725914}. |
| Tissue specificity: | |
Brain-specific (peripheral sensory neurons). {ECO:0000269|PubMed:9725914}. |
| Developmental stage: | |
Expressed in neurons after maturation. |
| Ptm: | |
Constitutively phosphorylated by CDK5 in nerve terminals and dephosphorylated by calcineurin when synaptic vesicle endocytosis (SVE) is stimulated by depolarization-dependent calcium influx. {ECO:0000269|PubMed:12855954, ECO:0000269|PubMed:17376771}. |
| Miscellaneous: | |
[Isoform 2]: Localized to numerous punctate spots of various sizes distributed along the plasma membrane and throughout the cytoplasm. {ECO:0000305}. |
| Miscellaneous: | |
[Isoform 6]: Diffuse cytoplasmic distribution with some localization to the Golgi apparatus. {ECO:0000305}. |
| Similarity: | |
Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. {ECO:0000255|PROSITE- ProRule:PRU01055}. |
Annotations taken from UniProtKB at the EBI.