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UniProt functional annotation for Q8L7L8 | ||
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| UniProt code: Q8L7L8. |
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| Organism: | |
Arabidopsis thaliana (Mouse-ear cress). |
| Taxonomy: | |
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis. |
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| Function: | |
Binds specifically to the plant telomeric double-stranded DNA sequences 5'-GGTTTAG-3'. At least 4 repeats of telomeric sequences are required for binding. Induces DNA bending. |
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| Subunit: | |
Homodimer and heterodimer with TRP2 and TRP3. Interacts with KU70. {ECO:0000269|PubMed:15364931, ECO:0000269|PubMed:15589838}. |
| Subcellular location: | |
Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}. |
| Tissue specificity: | |
Expressed ubiquitously. Highest expression in flowers and leaves. {ECO:0000269|PubMed:15364931, ECO:0000269|PubMed:15688221}. |
| Domain: | |
A N-terminal domain (80-269) is responsible for the interaction with KU70. |
| Domain: | |
The C-terminal domain (464-578) is sufficient for telomere binding. |
| Disruption phenotype: | |
No visible phenotype, probably due to redundancy. {ECO:0000269|PubMed:15364931}. |
Annotations taken from UniProtKB at the EBI.