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UniProt functional annotation for Q06850 | ||
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| UniProt code: Q06850. |
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| Organism: | |
Arabidopsis thaliana (Mouse-ear cress). |
| Taxonomy: | |
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis. |
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| Function: | |
May play a role in signal transduction pathways that involve calcium as a second messenger. Phosphorylates the Ca(2+)-ATPase ACA2 resulting in the inhibition of its calcium activation. {ECO:0000269|PubMed:10747788, ECO:0000269|PubMed:10823962, ECO:0000269|PubMed:8003490, ECO:0000269|PubMed:8855961}. |
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| Catalytic activity: | |
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; |
| Catalytic activity: | |
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; |
| Activity regulation: | |
Activated by calcium. Autophosphorylation may play an important role in the regulation of the kinase activity. {ECO:0000269|PubMed:8855961}. |
| Subunit: | |
Interacts with 14-3-3 proteins. {ECO:0000269|PubMed:16430916, ECO:0000269|PubMed:9688575}. |
| Subcellular location: | |
Peroxisome membrane {ECO:0000269|PubMed:12913141}; Lipid-anchor {ECO:0000269|PubMed:12913141}. |
| Domain: | |
There are 3 contiguous domains conserved in the CDPK subfamily: a kinase domain, an autoinhibitory (junction) domain and a calmodulin- like domain. The autoinhibitory domain (414-444) inactivates kinase activity under calcium-free conditions. {ECO:0000269|PubMed:10747788}. |
| Similarity: | |
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily. {ECO:0000255|PROSITE-ProRule:PRU00159}. |
Annotations taken from UniProtKB at the EBI.