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UniProt functional annotation for P43890 | ||
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| UniProt code: P43890. |
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| Organism: | |
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales; Pasteurellaceae; Haemophilus. |
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| Function: | |
Catalyzes the reversible phosphorylation of UMP to UDP. {ECO:0000269|PubMed:17210578}. |
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| Catalytic activity: | |
Reaction=ATP + UMP = ADP + UDP; Xref=Rhea:RHEA:24400, ChEBI:CHEBI:30616, ChEBI:CHEBI:57865, ChEBI:CHEBI:58223, ChEBI:CHEBI:456216; EC=2.7.4.22; |
| Activity regulation: | |
Allosterically activated by GTP. Inhibited by UTP. {ECO:0000269|PubMed:17210578}. |
| Biophysicochemical properties: | |
Kinetic parameters: KM=1.57 mM for ATP (in the absence of GTP) {ECO:0000269|PubMed:17210578}; KM=0.46 mM for ATP (in the presence of GTP) {ECO:0000269|PubMed:17210578}; KM=40 uM for UMP {ECO:0000269|PubMed:17210578}; Vmax=57 umol/min/mg enzyme {ECO:0000269|PubMed:17210578}; |
| Pathway: | |
Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1. |
| Subunit: | |
Homohexamer. {ECO:0000269|PubMed:17210578}. |
| Subcellular location: | |
Cytoplasm {ECO:0000250}. |
| Similarity: | |
Belongs to the UMP kinase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.