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PDBsum entry 2xny

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protein Protein-protein interface(s) links
Cell adhesion PDB id
2xny
Jmol
Contents
Protein chains
57 a.a.
298 a.a.
288 a.a.
37 a.a.
36 a.a.
PDB id:
2xny
Name: Cell adhesion
Title: A fragment of streptococcal m1 protein in complex with human fibrinogen
Structure: Fibrinogen alpha chain. Chain: a, d. Fragment: fragment d, residues 130-216. Synonym: fibrinopeptide a, human fibrinogen. Fibrinogen beta chain. Chain: b, e. Fragment: fragment d, residues 164-491. Synonym: human fibrinogen, fibrinopeptide b. Fibrinogen gamma chain.
Source: Homo sapiens. Human. Organism_taxid: 9606. Streptococcus pyogenes. Organism_taxid: 1314. Strain: 5448. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Resolution:
7.50Å     R-factor:   0.423     R-free:   0.408
Authors: P.Macheboeuf,C.Y Fu,A.S.Zinkernagel,J.E.Johnson,V.Nizet,P.Gh
Key ref: P.Macheboeuf et al. (2011). Streptococcal M1 protein constructs a pathological host fibrinogen network. Nature, 472, 64-68. PubMed id: 21475196
Date:
06-Aug-10     Release date:   13-Apr-11    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
P02671  (FIBA_HUMAN) -  Fibrinogen alpha chain
Seq:
Struc:
 
Seq:
Struc:
866 a.a.
57 a.a.
Protein chains
Pfam   ArchSchema ?
P02675  (FIBB_HUMAN) -  Fibrinogen beta chain
Seq:
Struc:
491 a.a.
298 a.a.
Protein chains
Pfam   ArchSchema ?
P02679  (FIBG_HUMAN) -  Fibrinogen gamma chain
Seq:
Struc:
453 a.a.
288 a.a.
Protein chain
Pfam   ArchSchema ?
Q48WD8  (Q48WD8_STRP1) -  M protein
Seq:
Struc:
484 a.a.
37 a.a.
Protein chain
Pfam   ArchSchema ?
Q48WD8  (Q48WD8_STRP1) -  M protein
Seq:
Struc:
484 a.a.
36 a.a.
Key:    PfamA domain  PfamB domain  Secondary structure

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     fibrinogen complex   1 term 
  Biological process     signal transduction   3 terms 
  Biochemical function     receptor binding     2 terms  

 

 
Nature 472:64-68 (2011)
PubMed id: 21475196  
 
 
Streptococcal M1 protein constructs a pathological host fibrinogen network.
P.Macheboeuf, C.Buffalo, C.Y.Fu, A.S.Zinkernagel, J.N.Cole, J.E.Johnson, V.Nizet, P.Ghosh.
 
  ABSTRACT  
 
No abstract given.