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PDBsum entry 2xnx

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protein Protein-protein interface(s) links
Cell adhesion PDB id
2xnx
Jmol
Contents
Protein chains
75 a.a.
313 a.a.
303 a.a.
76 a.a.
108 a.a.
PDB id:
2xnx
Name: Cell adhesion
Title: Bc1 fragment of streptococcal m1 protein in complex with hum fibrinogen
Structure: Fibrinogen alpha chain. Chain: a, d, g, j. Fragment: fragment d, residues 130-216. Synonym: human fibrinogen. Fibrinogen beta chain. Chain: b, e, h, k. Fragment: fragment d, residues 164-491. Synonym: human fibrinogen. Fibrinogen gamma chain.
Source: Homo sapiens. Human. Organism_taxid: 9606. Streptococcus pyogenes. Group a streptococcus. Organism_taxid: 1314. Strain: 5448. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Resolution:
3.30Å     R-factor:   0.279     R-free:   0.325
Authors: P.Macheboeuf,C.Y Fu,A.S.Zinkernagel,J.E.Johnson,V.Nizet,P.Gh
Key ref: P.Macheboeuf et al. (2011). Streptococcal M1 protein constructs a pathological host fibrinogen network. Nature, 472, 64-68. PubMed id: 21475196
Date:
06-Aug-10     Release date:   13-Apr-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P02671  (FIBA_HUMAN) -  Fibrinogen alpha chain
Seq:
Struc:
 
Seq:
Struc:
866 a.a.
75 a.a.
Protein chains
Pfam   ArchSchema ?
P02675  (FIBB_HUMAN) -  Fibrinogen beta chain
Seq:
Struc:
491 a.a.
313 a.a.
Protein chains
Pfam   ArchSchema ?
P02679  (FIBG_HUMAN) -  Fibrinogen gamma chain
Seq:
Struc:
453 a.a.
303 a.a.
Protein chain
Pfam   ArchSchema ?
P02671  (FIBA_HUMAN) -  Fibrinogen alpha chain
Seq:
Struc:
 
Seq:
Struc:
866 a.a.
76 a.a.
Protein chains
Pfam   ArchSchema ?
Q48WD8  (Q48WD8_STRP1) -  M protein
Seq:
Struc:
484 a.a.
108 a.a.*
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     fibrinogen complex   1 term 
  Biological process     signal transduction   3 terms 
  Biochemical function     receptor binding     2 terms  

 

 
Nature 472:64-68 (2011)
PubMed id: 21475196  
 
 
Streptococcal M1 protein constructs a pathological host fibrinogen network.
P.Macheboeuf, C.Buffalo, C.Y.Fu, A.S.Zinkernagel, J.N.Cole, J.E.Johnson, V.Nizet, P.Ghosh.
 
  ABSTRACT  
 
No abstract given.