PDBsum entry 2wxy

Hormone

PDB id

2wxy

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Contents

			Protein chain

					419 a.a. *

			Ligands

					EDO ×5

			Metals

					_NA ×4

			Waters ×148

* Residue conservation analysis

PDB id:

2wxy

Links

Name:

Hormone

Title:

Crystal structure of mouse angiotensinogen in the reduced form

Structure:

Angiotensinogen. Chain: c. Synonym: serpin a8. Engineered: yes

Source:

Mus musculus. Mouse. Organism_taxid: 10090. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

2.10Å

R-factor:

0.220

R-free:

0.242

Authors:

A.Zhou,Z.Wei,R.W.Carrell,R.J.Read

Key ref:

A.Zhou et al. (2010). A redox switch in angiotensinogen modulates angiotensin release. Nature, 468, 108-111. PubMed id: 20927107

Date:

11-Nov-09

Release date:

20-Oct-10

PROCHECK

	Headers

	References

Protein chain

P11859 (ANGT_MOUSE) - Angiotensinogen from Mus musculus

Seq: Struc:					477 a.a. 419 a.a.*

Key:

PfamA domain

Secondary structure

CATH domain

* PDB and UniProt seqs differ at 5 residue positions (black crosses)



		Enzyme reactions

Enzyme class:

E.C.?

[IntEnz] [ExPASy] [KEGG] [BRENDA]

	Nature 468:108-111 (2010)
PubMed id: 20927107

A redox switch in angiotensinogen modulates angiotensin release.
A.Zhou, R.W.Carrell, M.P.Murphy, Z.Wei, Y.Yan, P.L.Stanley, P.E.Stein, F.Broughton Pipkin, R.J.Read.

ABSTRACT

No abstract given.

Literature references that cite this PDB file's key reference

PubMed id

Reference

21269877

A.M.Allen (2011).
Role of angiotensin in the rostral ventrolateral medulla in the development and maintenance of hypertension.

Curr Opin Pharmacol, 11, 117-123.

21256016

J.B.Robbins, D.Smith, and M.Belfort (2011).
Redox-responsive zinc finger fidelity switch in homing endonuclease and intron promiscuity in oxidative stress.

Curr Biol, 21, 243-248.

21339086

L.G.Navar, M.C.Prieto, R.Satou, and H.Kobori (2011).
Intrarenal angiotensin II and its contribution to the genesis of chronic hypertension.

Curr Opin Pharmacol, 11, 180-186.

21048758

C.D.Sigmund (2010).
Structural biology: On stress and pressure.

Nature, 468, 46-47.

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.