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PDBsum entry 2lp1

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protein links
Membrane protein PDB id
2lp1
Jmol
Contents
Protein chain
46 a.a.
PDB id:
2lp1
Name: Membrane protein
Title: The solution nmr structure of the transmembranE C-terminal d the amyloid precursor protein (c99)
Structure: C99. Chain: a. Fragment: unp residues 683-728. Synonym: amyloid beta a4 protein, abpp, appi, app, alzheime amyloid protein, cerebral vascular amyloid peptide, cvap, p protease nexin-ii, pn-ii. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: a4, ad1, app. Expressed in: escherichia coli. Expression_system_taxid: 562.
NMR struc: 30 models
Authors: P.J.Barrett,Y.Song,W.D.Van Horn,E.J.Hustedt,J.M.Schafer, A.Hadziselimovic,A.J.Beel,C.R.Sanders
Key ref: P.J.Barrett et al. (2012). The amyloid precursor protein has a flexible transmembrane domain and binds cholesterol. Science, 336, 1168-1171. PubMed id: 22654059 DOI: 10.1126/science.1219988
Date:
30-Jan-12     Release date:   06-Jun-12    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
P05067  (A4_HUMAN) -  Amyloid beta A4 protein
Seq:
Struc:
 
Seq:
Struc:
770 a.a.
46 a.a.
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     integral to membrane   1 term 
  Biological process     nervous system development   1 term 

 

 
DOI no: 10.1126/science.1219988 Science 336:1168-1171 (2012)
PubMed id: 22654059  
 
 
The amyloid precursor protein has a flexible transmembrane domain and binds cholesterol.
P.J.Barrett, Y.Song, W.D.Van Horn, E.J.Hustedt, J.M.Schafer, A.Hadziselimovic, A.J.Beel, C.R.Sanders.
 
  ABSTRACT  
 
No abstract given.