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PDBsum entry 2lb2

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protein Protein-protein interface(s) links
Signaling protein/transcription PDB id
2lb2
Jmol
Contents
Protein chains
35 a.a.
12 a.a.
PDB id:
2lb2
Name: Signaling protein/transcription
Title: Structure of the second domain of human nedd4l in complex wi phosphorylated ptpy motif derived from human smad3
Structure: E3 ubiquitin-protein ligase nedd4-like. Chain: a. Fragment: residues 386-420. Synonym: nedd4.2, nedd4-2. Engineered: yes. Mothers against decapentaplegic homolog 3. Chain: b. Fragment: residues 178-189. Synonym: mad homolog 3, mad3, mothers against dpp homolog 3
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: nedd4l, kiaa0439, nedl3. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606
NMR struc: 25 models
Authors: M.J.Macias,E.Aragon,N.Goerner,A.Zaromytidou,Q.Xi,A.Escobedo, J.Massague
Key ref: E.Aragón et al. (2011). A Smad action turnover switch operated by WW domain readers of a phosphoserine code. Genes Dev, 25, 1275-1288. PubMed id: 21685363 DOI: 10.1101/gad.2060811
Date:
22-Mar-11     Release date:   06-Jul-11    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q96PU5  (NED4L_HUMAN) -  E3 ubiquitin-protein ligase NEDD4-like
Seq:
Struc:
 
Seq:
Struc:
975 a.a.
35 a.a.
Protein chain
Pfam   ArchSchema ?
P84022  (SMAD3_HUMAN) -  Mothers against decapentaplegic homolog 3
Seq:
Struc:
425 a.a.
12 a.a.*
Key:    PfamA domain  Secondary structure
* PDB and UniProt seqs differ at 1 residue position (black cross)

 

 
DOI no: 10.1101/gad.2060811 Genes Dev 25:1275-1288 (2011)
PubMed id: 21685363  
 
 
A Smad action turnover switch operated by WW domain readers of a phosphoserine code.
E.Aragón, N.Goerner, A.I.Zaromytidou, Q.Xi, A.Escobedo, J.Massagué, M.J.Macias.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
22992590 J.Massagué (2012).
TGFβ signalling in context.
  Nat Rev Mol Cell Biol, 13, 616-630.  
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