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PDBsum entry 2kyl

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protein Protein-protein interface(s) links
Transferase PDB id
2kyl
Jmol
Contents
Protein chains
96 a.a.
13 a.a.
PDB id:
2kyl
Name: Transferase
Title: Solution structure of mast2-pdz complexed with thE C-terminu
Structure: Microtubule-associated serine/threonine-protein k chain: a. Fragment: pdz domain. Engineered: yes. C-terminus of phosphatidylinositol-3,4,5-trisphos phosphatase and dual-specificity protein phosphatase pten. Chain: b. Synonym: c-terminus of pten. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetic peptide
NMR struc: 10 models
Authors: E.Terrien,N.Wolff,F.Cordier,C.Simenel,M.Lafon,M.Delepierre
Date:
01-Jun-10     Release date:   08-Jun-11    
PROCHECK
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 Headers
 References

Protein chain
No UniProt id for this chain
Struc: 96 a.a.
Protein chain
Pfam   ArchSchema ?
P60484  (PTEN_HUMAN) -  Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Seq:
Struc:
403 a.a.
13 a.a.
Protein chain
Pfam   ArchSchema ?
Q6P0Q8  (MAST2_HUMAN) -  Microtubule-associated serine/threonine-protein kinase 2
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
1798 a.a.
13 a.a.*
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 10 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class 1: Chain B: E.C.3.1.3.16  - Protein-serine/threonine phosphatase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: [a protein]-serine/threonine phosphate + H2O = [a protein]- serine/threonine + phosphate
[a protein]-serine/threonine phosphate
+ H(2)O
= [a protein]- serine/threonine
+ phosphate
   Enzyme class 2: Chain B: E.C.3.1.3.48  - Protein-tyrosine-phosphatase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Protein tyrosine phosphate + H2O = protein tyrosine + phosphate
Protein tyrosine phosphate
+ H(2)O
= protein tyrosine
+ phosphate
   Enzyme class 3: Chain B: E.C.3.1.3.67  - Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
      Reaction: Phosphatidylinositol 3,4,5-trisphosphate + H2O = phosphatidylinositol 4,5-bisphosphate + phosphate
Phosphatidylinositol 3,4,5-trisphosphate
+ H(2)O
= phosphatidylinositol 4,5-bisphosphate
+ phosphate
      Cofactor: Mg(2+)
   Enzyme class 4: Chain B: E.C.2.7.11.1  - Non-specific serine/threonine protein kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + a protein = ADP + a phosphoprotein
ATP
+ protein
= ADP
+ phosphoprotein
Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     regulation of interleukin-12 biosynthetic process   1 term 
  Biochemical function     protein serine/threonine kinase activity     1 term