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PDBsum entry 2hbu

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protein ligands metals links
Oxidoreductase PDB id
2hbu
Jmol
Contents
Protein chain
219 a.a. *
Ligands
UN9
Metals
FE2
Waters ×121
* Residue conservation analysis
PDB id:
2hbu
Name: Oxidoreductase
Title: Crystal structure of hif prolyl hydroxylase egln-1 in complex with a biologically active inhibitor
Structure: Egl nine homolog 1. Chain: a. Fragment: catalytic domain. Synonym: hypoxia-inducible factor prolyl hydroxylase 2, hif-prolyl hydroxylase 2, hif-ph2, hph-2, prolyl hydroxylase domain-containing protein 2, phd2, sm-20. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: egln1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Biol. unit: Trimer (from PQS)
Resolution:
1.85Å     R-factor:   0.181     R-free:   0.231
Authors: A.G.Evdokimov,R.L.Walter,M.Mekel,M.E.Pokross,R.Kawamoto, A.Boyer
Key ref: A.G.Evdokimov et al. Crystal structure of hif prolyl hydroxylase in complex with a biologically active inhibitor. To be published, .
Date:
14-Jun-06     Release date:   27-Jun-06    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q9GZT9  (EGLN1_HUMAN) -  Egl nine homolog 1
Seq:
Struc:
426 a.a.
219 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.1.14.11.29  - Hypoxia-inducible factor-proline dioxygenase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2 = hypoxia- inducible factor-trans-4-hydroxy-L-proline + succinate + CO2
Hypoxia-inducible factor-L-proline
+ 2-oxoglutarate
+ O(2)
= hypoxia- inducible factor-trans-4-hydroxy-L-proline
+ succinate
+ CO(2)
      Cofactor: Fe(2+); L-ascorbate
Fe(2+)
L-ascorbate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     oxidation-reduction process   1 term 
  Biochemical function     oxidoreductase activity     5 terms