spacer
spacer

PDBsum entry 2h5g

Go to PDB code: 
protein ligands links
Oxidoreductase PDB id
2h5g
Jmol
Contents
Protein chain
417 a.a. *
Ligands
SO4 ×6
Waters ×282
* Residue conservation analysis
PDB id:
2h5g
Name: Oxidoreductase
Title: Crystal structure of human pyrroline-5-carboxylate synthetas
Structure: Delta 1-pyrroline-5-carboxylate synthetase. Chain: a, b. Fragment: gamma-glutamyl phosphate reductase. Synonym: pyrroline-5-carboxylate synthetase isoform 1, pycs aldehyde dehydrogenase 18 family member a1. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: aldh18a1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Biol. unit: Dimer (from PDB file)
Resolution:
2.25Å     R-factor:   0.232     R-free:   0.272
Authors: E.Papagrigoriou,N.Shafqat,A.P.Turnbull,G.Berridge,V.Hozjan, K.Kavanagh,O.Gileadi,C.Smee,J.Bray,F.Gorrec,M.Sundstrom, C.Arrowsmith,J.Weigelt,A.Edwards,U.Oppermann,Structural Gen Consortium (Sgc)
Key ref: E.Papagrigoriou et al. Crystal structure of human pyrroline-5-Carboxylate synthetase. To be published, .
Date:
26-May-06     Release date:   23-Jun-06    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P54886  (P5CS_HUMAN) -  Delta-1-pyrroline-5-carboxylate synthase
Seq:
Struc:
 
Seq:
Struc:
795 a.a.
417 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class 1: E.C.1.2.1.41  - Glutamate-5-semialdehyde dehydrogenase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
Proline Biosynthesis
      Reaction: L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH
L-glutamate 5-semialdehyde
+ phosphate
+ NADP(+)
= L-glutamyl 5-phosphate
+ NADPH
   Enzyme class 2: E.C.2.7.2.11  - Glutamate 5-kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
      Reaction: ATP + L-glutamate = ADP + L-glutamate 5-phosphate
ATP
+ L-glutamate
= ADP
+ L-glutamate 5-phosphate
Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     metabolic process   3 terms 
  Biochemical function     catalytic activity     4 terms