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PDBsum entry 2g64

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protein ligands metals links
Lyase PDB id
2g64
Jmol
Contents
Protein chain
140 a.a. *
Ligands
GOL
Metals
_NA ×2
_ZN
Waters ×167
* Residue conservation analysis
PDB id:
2g64
Name: Lyase
Title: Structure of caenorhabditis elegans 6-pyruvoyl tetrahydropte synthase
Structure: Putative 6-pyruvoyl tetrahydrobiopterin synthase. Chain: a. Synonym: ptps, ptp synthase. Engineered: yes. Mutation: yes
Source: Caenorhabditis elegans. Organism_taxid: 6239. Gene: b0041.6. Expressed in: escherichia coli. Expression_system_taxid: 562.
Biol. unit: Hexamer (from PDB file)
Resolution:
1.80Å     R-factor:   0.162     R-free:   0.219
Authors: B.C.Wengerter,Y.Patskovsky,C.Zhan,U.Ramagopal,S.Milstein,M.V S.C.Almo,S.K.Burley,New York Sgx Research Center For Struct Genomics (Nysgxrc)
Key ref: B.C.Wengerter et al. Crystal structure of caenorhabditis elegans 6-Pyruvoyl tetrahydropterin synthase. To be published, .
Date:
24-Feb-06     Release date:   14-Mar-06    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
O02058  (PTPS_CAEEL) -  Putative 6-pyruvoyl tetrahydrobiopterin synthase
Seq:
Struc:
140 a.a.
140 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: E.C.4.2.3.12  - 6-pyruvoyltetrahydropterin synthase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
Biopterin Biosynthesis
      Reaction: 7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8- tetrahydropterin + triphosphate
7,8-dihydroneopterin 3'-triphosphate
= 6-pyruvoyl-5,6,7,8- tetrahydropterin
+ triphosphate
      Cofactor: Mg(2+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     tetrahydrobiopterin biosynthetic process   1 term 
  Biochemical function     lyase activity     4 terms