PDBsum entry 2eqe

Hydrolase

PDB id: 2eqe

Contents

Protein chain

48 a.a. *

Metals

_ZN

* Residue conservation analysis

PDB id:

2eqe

Name:

Hydrolase

Title:

Solution structure of the fourth a20-type zinc finger domain from human tumor necrosis factor, alpha-induced protein3

Structure:

Tumor necrosis factor, alpha-induced protein 3. Chain: a. Fragment: a20-type zinc finger domain. Synonym: putative DNA-binding protein a20, zinc finger protein a20. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: tnfaip3. Other_details: cell-free protein synthesis

NMR struc:

20 models

Authors:

H.P.Zhang,T.Nagasima,F.Hayahsi,S.Yokoyama,Riken Structural Genomics/proteomics Initiative (Rsgi)

Key ref:

H.P.Zhang et al. Solution structure of the fourth a20-Type zinc finger domain from human tumor necrosis factor, Alpha-Induced protein3. To be published, .

Date:

30-Mar-07 Release date: 02-Oct-07

Protein chain

P21580  (TNAP3_HUMAN) -  Tumor necrosis factor alpha-induced protein 3 from Homo sapiens

Seq: 790 a.a.

Struc: 48 a.a.*

* PDB and UniProt seqs differ at 12 residue positions (black crosses)

Enzyme reactions

• Enzyme class 1: E.C.2.3.2.- - ?????
• Enzyme class 2: E.C.3.4.19.12 - ubiquitinyl hydrolase 1.
• Reaction: Thiol-dependent hydrolysis of ester, thiolester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.