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PDBsum entry 2cq8

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protein links
Oxidoreductase PDB id
2cq8
Jmol
Contents
Protein chain
110 a.a. *
* Residue conservation analysis
PDB id:
2cq8
Name: Oxidoreductase
Title: Solution structure of rsgi ruh-033, a pp-binding domain of 10-fthfdh from human cdna
Structure: 10-formyltetrahydrofolate dehydrogenase. Chain: a. Fragment: pp-binding domain. Synonym: 10-fthfdh, aldehyde dehydrogenase 1 family member l1. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fthfd. Other_details: cell-free protein synthesis
NMR struc: 20 models
Authors: T.Abe,H.Hirota,F.Hayashi,S.Yokoyama,Riken Structural Genomics/proteomics Initiative (Rsgi)
Key ref: T.Abe et al. Solution structure of rsgi ruh-033, A pp-Binding domain of 10-Fthfdh from human cdna. To be published, .
Date:
19-May-05     Release date:   19-Nov-05    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
O75891  (AL1L1_HUMAN) -  Cytosolic 10-formyltetrahydrofolate dehydrogenase
Seq:
Struc:
 
Seq:
Struc:
902 a.a.
110 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 11 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: E.C.1.5.1.6  - Formyltetrahydrofolate dehydrogenase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
Folate Coenzymes
      Reaction: 10-formyltetrahydrofolate + NADP+ + H2O = tetrahydrofolate + CO2 + NADPH
10-formyltetrahydrofolate
+ NADP(+)
+ H(2)O
= tetrahydrofolate
+ CO(2)
+ NADPH
Molecule diagrams generated from .mol files obtained from the KEGG ftp site