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PDBsum entry 2bpo

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protein ligands Protein-protein interface(s) links
Reductase PDB id
2bpo
Jmol
Contents
Protein chains
641 a.a. *
Ligands
FAD ×2
FMN ×2
NAP ×2
SO4 ×3
Waters ×185
* Residue conservation analysis
PDB id:
2bpo
Name: Reductase
Title: Crystal structure of the yeast cpr triple mutant: d74g, y75f, k78a.
Structure: NADPH-cytochrom p450 reductase. Chain: a, b. Synonym: cpr, p450r. Engineered: yes. Mutation: yes
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
2.90Å     R-factor:   0.205     R-free:   0.268
Authors: L.V.Yermalitskaya,Y.Kim,M.R.Waterman,L.M.Podust
Key ref: L.V.Yermalitskaya et al. Crystal structure of the yeast cpr triple mutant: d74g, Y75f, K78a.. To be published, .
Date:
21-Apr-05     Release date:   13-Jul-06    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P16603  (NCPR_YEAST) -  NADPH--cytochrome P450 reductase
Seq:
Struc:
 
Seq:
Struc:
691 a.a.
641 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 3 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: E.C.1.6.2.4  - NADPH--hemoprotein reductase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: NADPH + n oxidized hemoprotein = NADP+ + n reduced hemoprotein
NADPH
+ n oxidized hemoprotein
= NADP(+)
+ n reduced hemoprotein
      Cofactor: FAD; FMN
FAD
Bound ligand (Het Group name = FAD) corresponds exactly
FMN
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     membrane   8 terms 
  Biological process     oxidation-reduction process   6 terms 
  Biochemical function     electron carrier activity     5 terms