 |
PDBsum entry 2b60
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Hydrolase/hydrolase inhibitor
|
PDB id
|
|
|
|
2b60
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
Contents |
 |
|
|
|
|
|
|
|
|
|
|
|
|
* Residue conservation analysis
|
|
|
|
|
|
PDB id:
|
|
|
|
| Name: |
|
Hydrolase/hydrolase inhibitor
|
|
|
Title:
|
|
Structure of HIV-1 protease mutant bound to ritonavir
|
|
Structure:
|
|
Gag-pol polyprotein. Chain: a, b. Fragment: protease. Engineered: yes. Mutation: yes
|
|
Source:
|
|
Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
Biol. unit:
|
|
Dimer (from
)
|
|
Resolution:
|
|
|
2.20Å
|
R-factor:
|
0.216
|
R-free:
|
0.245
|
|
|
Authors:
|
|
J.C.Clemente,L.R.Stow,L.K.Janka,J.A.Jeung,K.A.Desai,L.Govindasamy, M.Agbandje-Mckenna,R.Mckenna,M.M.Goodenow,B.M.Dunn
|
|
Key ref:
|
|
J.C.Clemente
et al.
In vivo, Kinetic, And structural analysis of the development of ritonavir resistance.
To be published,
.
|
|
|
Date:
|
|
|
29-Sep-05
|
Release date:
|
14-Nov-06
|
|
|
|
|
|
|
PROCHECK
|
|
|
|
|
|
Headers
|
|
|
|
References
|
|
|
|
|
|
|
|
Q7SMT3
(Q7SMT3_9HIV1) -
Pol polyprotein (Fragment) from Human immunodeficiency virus 1
|
|
|
|
Seq:
Struc:
|
|
|
|
358 a.a.
99 a.a.*
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Key: |
 |
PfamA domain |
|
|
 |
Secondary structure |
|
 |
CATH domain |
|
|
*
PDB and UniProt seqs differ
at 4 residue positions (black
crosses)
|
|
|
|
|
|
|
Links
