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PDBsum entry 2ar5

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protein ligands links
Transferase PDB id
2ar5
Jmol
Contents
Protein chain
117 a.a. *
Ligands
GOL ×6
Waters ×92
* Residue conservation analysis
PDB id:
2ar5
Name: Transferase
Title: Crystal structure of the mammalian c2alpha-pi3 kinase px-dom
Structure: Phosphoinositide 3-kinase. Chain: a. Fragment: px-domain, residues 1421-1532. Synonym: phosphatidylinositol-4-phosphate 3-kinase c2 domai containing alpha polypeptide, phosphoinositide 3-kinase-c2- ptdins-3-kinase c2 alpha, pi3k-c2alpha. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pi3kc2a. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
1.80Å     R-factor:   0.223     R-free:   0.244
Authors: G.N.Parkinson,D.Vines,P.C.Driscoll,S.Djordjevic
Key ref: G.N.Parkinson et al. Ligand-Binding specificity of pi3kinase c2alpha px domain.. To be published, .
Date:
19-Aug-05     Release date:   24-Oct-06    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
O00443  (P3C2A_HUMAN) -  Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
1686 a.a.
117 a.a.*
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 5 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: E.C.2.7.1.154  - Phosphatidylinositol-4-phosphate 3-kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
1-Phosphatidyl-myo-inositol Metabolism
      Reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl- 1D-myo-inositol 3,4-bisphosphate
ATP
+ 1-phosphatidyl-1D-myo-inositol 4-phosphate
= ADP
+ 1-phosphatidyl- 1D-myo-inositol 3,4-bisphosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biochemical function     phosphatidylinositol binding     1 term