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PDBsum entry 2ae8

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protein metals Protein-protein interface(s) links
Lyase PDB id
2ae8
Jmol
Contents
Protein chains
(+ 0 more) 171 a.a. *
Metals
_MG ×16
Waters ×946
* Residue conservation analysis
PDB id:
2ae8
Name: Lyase
Title: Crystal structure of imidazoleglycerol-phosphate dehydratase staphylococcus aureus subsp. Aureus n315
Structure: Imidazoleglycerol-phosphate dehydratase. Chain: a, b, c, d, e, f. Synonym: igpd. Engineered: yes
Source: Staphylococcus aureus subsp. Aureus. Organism_taxid: 158879. Strain: n315. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Biol. unit: 24mer (from PQS)
Resolution:
2.01Å     R-factor:   0.192     R-free:   0.226
Authors: Y.Kim,P.Quartey,D.Holzle,F.Collart,A.Joachimiak,Midwest Cent Structural Genomics (Mcsg)
Key ref: Y.Kim et al. Crystal structure of imidazoleglycerol-Phosphate dehydratase from staphylococcus aureus subsp. Aureus n315. To be published, .
Date:
21-Jul-05     Release date:   06-Sep-05    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
P64373  (HIS7_STAAN) -  Imidazoleglycerol-phosphate dehydratase
Seq:
Struc:
192 a.a.
171 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.4.2.1.19  - Imidazoleglycerol-phosphate dehydratase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
Histidine Biosynthesis (late stages)
      Reaction: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2- oxopropyl phosphate + H2O
D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate
= 3-(imidazol-4-yl)-2- oxopropyl phosphate
+ H(2)O
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cytoplasm   1 term 
  Biological process     cellular amino acid biosynthetic process   2 terms 
  Biochemical function     lyase activity     2 terms